Healthy
Conditions
Keywords
Leptin, Changes in leptin may precede the, phasing of oscillations of dietary fat intake
Brief summary
The purpose of this study is to understand the mechanisms for oscillations of dietary fat/carbohydrate intake and how fat intake affect insulin resistance and liver fat over interval of 3 to 4 days.
Detailed description
You will be expected to keep diet records for 17 consecutive days. You will start with a fasting screening visit (only water allowed). A physical exam and Medical history it taken at screening visit. Your body composition will be gathered by CT and Dexa Scan. Blood and urine will be collected for a chemical profile and other determinations. Questionnaires will be administered along with an accelerometer to be worn for the remainder of the study. The final day you will return the dietary records, accelerometer, and a few procedures will be performed as weight.
Interventions
OTHERDietary fat/intake of carbohydrate
Spontaneous intake of fat, carbohydrate, protein and alcohol each day for 17 days.
BEHAVIORALSpontaneous oscillations of dietary fat/intake of carbohydrate in relation to energy intake.
Dietitians and senior level or graduate level dietetics students who are not restrained eaters to participate in food intake over 17 days. During this same time interval, integrated energy expenditure will be recorded using doubly-labeled water and day to day energy expenditure by accelerometer. Periodic blood sampling for leptin will be done completed at site intervals.
Sponsors
Pennington Biomedical Research Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* You are a dietitian or a senior level or graduate level dietetics student * You are between the ages of 21-55 years inclusive and a nonsmoker * you are not a restrictive diet or strenuous exercise regimen * You typically eat several meals per day
Exclusion criteria
* You have an eating disorder or history * You abuse alcohol or other substances, and consume no more than 3 alcoholic drinks per day * You have no current regular use of some over-the-counter medication or prescription medication, excluding headache medicines, blood pressure medications, etc. * You have gained/lost more than 10 pounds of body weight in the last year * You have recently had or anticipating significant life changes during the course of your participation in the study. * You have an eating disorder or history * You have a major psychiatric illness or history * You have no serious current clinical disease or surgical condition that may interfere with the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mechanisms for oscillations of dietary fat/carbohydrate intake | 17 consecutive days (11 visits on site) | Test the spontaneous intake of fat, carbohydrate,protein and alcohol each day for 17 consecutive days. Examine spontaneous oscillations of dietary fat/intake of carbohydrate in relation to energy intake. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Energy Intake | 17 days | During the same time interval, integrated energy expenditure will be recoreded using doubly-labeled water and day to day energy expenditure by accelerometer. |
Countries
United States
Outcome results
None listed