Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients

Circulating Biomarkers as Prognostic Indicators of Death in Ambulatory Heart Failure Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01113866

Enrollment

124

Registered

2010-04-30

Start date

1998-10-31

Completion date

2009-01-31

Last updated

2010-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Brief summary

Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.

Detailed description

Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* symptomatic congestive heart failure lasting at least six months * reduced exercise tolerance * impaired or preserved left ventricular ejection fraction * cardiomegaly

Exclusion criteria

* acute infection * rheumatoid or other autoimmune diseases * primary cachectic states (cancer, thyroid disease, severe liver disease) * severe chronic lung disease * neuromuscular disorders * myocardial infarction within the previous 20 weeks * diabetes mellitus * chronic renal failure (serum creatinine level \> 2.0 mg/dl, \>177 micromol/L)

Countries

Italy

Outcome results