Fluid Responsiveness
Conditions
Keywords
pulse pressure variation, hemodynamic monitoring, fluid responsiveness, mechanical ventilation, fluid therapy
Brief summary
Fluid administration is a daily intervention on the intensive care unit to improve cardiac output (CO) and stabilize circulation in critically ill patients. Simultaneously, the volume status of the patient is very difficult to assess. Too little volume leads to inadequate organ perfusion followed by ischemia and organ failure. Too much volume may worsen heart failure and cause pulmonary and peripheral edema and contribute to further tissue injury and organ dysfunction. Although dynamic indices have been shown to be more accurate predictors of fluid responsiveness, this relevant and complex task is usually guided by static clinical variables and the specialist's interpretation due to the fact that the interpretation of dynamic parameters is not fully developed and that they are not universally available. This lack of understanding is partially because of the complex interaction with mechanical ventilation. The investigators hypothesize that knowing the distribution of ventilatory pressures will make it possible to index dynamic parameters to tidal volume and improve their predictive value concerning the volume status of the patient. In addition, it would be of interest to be able to predict fluid responsiveness in a non-invasive way, especially in critically ill patients. Up to now, continuous non-invasive cardiac output monitoring using Nexfin in critically ill patients has not been validated and also not tested for its ability to predict fluid responsiveness. The present research proposal evaluates the possibility and accuracy of the model flow analysis obtained by non-invasive finger arterial pressure measurements to determine fluid responsiveness using passive leg raising. It will also be compared to a more invasive method (that is currently used in the clinic) to assess its ability to measure absolute CO levels accurately. It may make it possible to assess fluid responsiveness in a non-invasive and patient friendly way.
Interventions
OTHERventilatory protocol
Ventilatory protocol for short period with four different tidal volumes (12 min)
OTHERElastic band
Placement of an elastic band around thorax to reduce thorax compliance
performing the passive leg raising test
Sponsors
Radboud University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Elective open heart surgery.
Exclusion criteria
* Significant cardiac arrhythmias, including atrial fibrillation. * Hemodynamical instability, as defined by a variation in heart rate, blood pressure and cardiac output of more than 10% during the 15-min period before starting the protocol. * Recent myocardial infarction (\< 3 mnd, troponine \> 50 ug/l).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fluid responsiveness | 30 minutes around fluid challenge | pulse pressure variation (PPV), systolic pressure variation (SPV), stroke volume variation (SVV), pre-ejection period variation (dPEP) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pressure distribution in thorax due to mechanical ventilation | 30 minutes of varying tidal volumes | mechanical ventilation with 4 different tidal volumes and decreased chest compliance |
| Dynamic indices in pressure support ventilation | 30 minutes of pressure support | — |
| non invasive prediction of fluid responsiveness | 30 minutes around fluid challenge | pulse contour analysis of cardiac output with finger cuff combined with passive leg raising test |
| pressure distribution and dynamic indices during spontaneous breathing | 5 minutes of spontaneous breathing | — |
Countries
Netherlands
Contacts
Primary ContactPeter Pickkers, MD, PhD
Outcome results
None listed