Coronary Artery Disease
Conditions
Keywords
Coronary Artery Disease, Aspirin, Secondary Prevention
Brief summary
Aspirin is an effective medicine for prevention of heart attacks in patients with coronary artery disease and works by preventing clots from forming. In previous studies aspirin has been found to be ineffective in between 2% and 65% of patients but none of these studies have looked specifically at coronary artery disease patients in Ireland. This study is being done to identify the percentage of patients in Ireland whose aspirin is not working effectively and help identify factors that could be used to target interventions to increase aspirin's effectiveness in Irish patients.
Interventions
None listed
Sponsors
Royal College of Surgeons, Ireland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years or older * Patients with documented coronary artery disease * Current treatment with any dose of aspirin daily for a minimum of 3 months * Able to provide written informed consent based on competent mental status
Exclusion criteria
* Myocardial infarction, unstable angina or stroke during the preceding three months * Platelet count \<125,000/mm * Known haematological disorders * Active malignancy on current chemotherapy or a recent diagnosis of cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of patients with non-response to aspirin | Following a minimum of 3 months of daily aspirin use | Prevalence of non-response to aspirin in coronary artery disease patients in Ireland by measurement of serum thromboxane B2 |
Countries
Ireland
Contacts
Primary ContactMary C De Voe, RN
Outcome results
None listed