Effect of Heart Rate on Left Ventricular Performance

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01112176

Enrollment

100

Registered

2010-04-28

Start date

2010-04-30

Completion date

2012-04-30

Last updated

2010-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Function, Myocardial Strain

Keywords

Strain, Ejection fraction, Diastolic function

Brief summary

The current study is aimed at determining the normal response to increasing heart rates. For this purpose, atrial pacing will be used to increase heart rate.

Detailed description

Participants will be patients with pacemakers and normal A-V node conduction with a possibility for right atrial pacing mode. Detailed Echo studies will be performed at baseline. Echo studies will be repeated at each pacing stage, stages defined as 10 bpm increments in paced heart rate. Each stage will last 2-3 min or as long as it takes to record the echo study. Heart rate will be increased to 85% of predicted heart rate for age or at to appearance of signs of ischemia. Hemodynamic parameters will be recorded and segmental longitudinal strain will be calculated (as well as other Echo data), for each stage.

Interventions

PROCEDUREIncrease in paced heart rate

The pacing rate will be increased by 10 bps at every stage

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients with AAI or DDD pacemaker with intact AV nodal conduction that can be set to work in AAI mode. 2. Stable rhythm (either sinus or paced). 3. Good quality baseline echo. 4. Able and willing to sign Informed Consent Form.

Exclusion criteria

1. Prior heart failure or ischemic heart disease. 2. Severe valvular lesions. 3. Severe pulmonary hypertension. 4. Known intolerance to rapid pacing. 5. Multiple extrasystoles (more than 1 per echo or monitor screen). 6. Age over 70.

Design outcomes

Primary

Measure	Time frame	Description
Segmental Strain	approx. 20 minutes	Segmental Strain by speckle tracking method will be calculated for every stage of each study.

Secondary

Measure	Time frame	Description
LV function	Approx. 20 minutes	Parameters of systolic and diastolic function will be calculated at each stage.

Countries

Israel

Contacts

Primary ContactDavid S. Blondheim, MD

davidb@hy.health.gov.il97246304488

Backup ContactDavid S. Blondheim, MD

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026