Does Local Injury of the Endometrium Improve Controlled Ovarian Hyperstimulation (COH) + Intrauterine Insemination (IUI) Outcome?

Exploration of the Possibility That Local Injury of the Endometrium Has the Same Beneficial Effect on IUI Outcome as Demonstrated in IVF Treatment

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01111799

Enrollment

600

Registered

2010-04-28

Start date

2010-06-30

Completion date

2012-10-31

Last updated

2012-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Implantation Failure, Infertility

Keywords

endometrial biopsy, implantation, uterine receptivity, infertility, controled ovarian hyperstimulation, intra uterine insemination

Brief summary

It was previously demonstrated in in vitro fertilization (IVF) patients that local injury of the endometrium during a spontaneous menstrual cycle that precedes IVF treatment doubled the rates of implantation and pregnancy. The hypothesis of our present study is that the endometrial injury procedure will have the same beneficial effect in patients undergoing controlled ovarian hyperstimulation (COH) combined with intrauterine insemination (IUI).

Detailed description

In order to test our hypothesis, we will perform the simple procedure of local injury of the endometrium using a Pipelle biopsy catheter during the spontaneous menstrual cycle that precedes a COH + IUI treatment.

Interventions

PROCEDUREendometrial biopsy

two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment.

PROCEDUREnatural cycle + IUI + endometrial biopsy

two endometrial biopsies will be taken with a PIPELLE catheter on days 12 and 21 of the spontaneous menstrual cycle that precedes the fertility treatment.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 38 Years

Healthy volunteers

Inclusion criteria

* age 18-38. * infertility. * patients undergoing IUI treatment. * at least one failed IUI cycle.

Exclusion criteria

* indication for IVF treatment. * Known Pelvic inflammatory disease(PID).

Design outcomes

Primary

Measure	Time frame
Clinical Pregnancy rate	1 year

Secondary

Measure	Time frame
Live birth	2 years

Countries

Israel

Contacts

Primary ContactYuval Or, MD

yuval_o@clalit.org.il+97289445150

Backup ContactLeila Aliger, MD

+97289445150

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026