Exercise-associated Hyponatremia
Conditions
Keywords
Exercise-associated hyponatremia, Randomized treatment trial, Endurance runners
Brief summary
The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral hypertonic saline (high salt) is as effective as intravenous administration of hypertonic saline to elevate below-normal blood salt concentrations (EAH) at the end of the Western States Endurance Run, and 3) determine if oral and intravenous hypertonic saline solutions are equally as effective at reversing mild (without altered mental status) symptoms associated with EAH.
Interventions
Intravenous 100mL bolus of 3% saline
OTHEROral hypertonic saline
Oral 100mL bolus of 3% saline
Sponsors
Western States Endurance Run Research Foundation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* consenting Western States 100 race finisher * hyponatremic
Exclusion criteria
* altered mental status
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood sodium concentration post administration of oral or IV hypertonic saline. | 1 hour post administration of hypertonic saline |
Countries
United States
Contacts
Primary ContactMartin D Hoffman, MD
Backup ContactBethan E Owen, BM
Outcome results
None listed