Left Ventricular Dysfunction
Conditions
Brief summary
Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart. The purpose of this study is to determine if the energy production is reduced in failing heart.
Detailed description
We will use non-invasive phosphorus magnetic resonance spectroscopy technique to measure creatine kinase (CK) flux in failing heart. The studies will be done on Siemens 3.0T human system. We will recruit subjects with LV dysfunction due to prior anterior wall myocardial infarction.
Interventions
DIAGNOSTIC_TESTMR Spectroscopy
MR spectroscopy of myocardial
Sponsors
Washington University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Individuals with left ventricular dysfunction
Exclusion criteria
* Age \< 18, pregnant, history of excessive alcohol use, or any condition (e.g. claustrophobia, a pacemaker) that would prevent him/her from completing the magnetic resonance spectroscopy study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| An MR Spectroscopy Showing Signal to Noise Ratio to Determine the Level of Heart Failure | 1-2 days |
Countries
United States
Participant flow
Recruitment details
Patients recruited from heart transplant clinic
Participants by arm
| Arm | Count |
|---|---|
| Heart Failure Magnetic Resonance Spectroscopy | 15 |
| Total | 15 |
Baseline characteristics
| Characteristic | Heart Failure |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 15 Participants |
| Sex: Female, Male Female | 2 Participants |
| Sex: Female, Male Male | 13 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 15 |
| other Total, other adverse events | 0 / 15 |
| serious Total, serious adverse events | 0 / 15 |
Outcome results
Primary
An MR Spectroscopy Showing Signal to Noise Ratio to Determine the Level of Heart Failure
Time frame: 1-2 days
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| MR Spectroscopy Post-Heart Transplant | An MR Spectroscopy Showing Signal to Noise Ratio to Determine the Level of Heart Failure | 7 Ratio | Standard Deviation 13.67 |
Comparison: We are unable to provide any further data that has been requested. We have supplied all the data that we can possibly provide because the PI has left the institution and we are unable to contact him. We have no other data.mean + SD
p-value: <0.05Mean + SD