Sarcopenia
Conditions
Keywords
sarcopenia, frail elderly, protein drink, resistance exercise, Skeletal muscle mass, muscle mass in elderly
Brief summary
The present study is designed to investigate whether timed protein supplementation will increase skeletal muscle mass in the frail elderly population.
Interventions
DIETARY_SUPPLEMENTProtein drink
Protein drink twice a day during 6 months.
OTHERResistance exercise training
Resistance exercise training twice per week during 6 months.
DIETARY_SUPPLEMENTPlacebo drink
Placebo drink twice a day during 6 months.
Sponsors
Top Institute Food and Nutrition
Maastricht University Medical Center
Wageningen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Frail elderly individuals * Able to understand and perform the study procedures
Exclusion criteria
* Type I or type II diabetes (fasted blood glucose level ≥7,0 mmol) * No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire) * Use of anti-coagulation medication (except of Acetyl Salicyl acid) * Presence of coronary heart disease (ECG) * Renal insufficiency (eGFR \<60 mL/min/1.73 m2) * Allergic or sensitive for milk proteins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in skeletal muscle mass | Baseline, 3 months and 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Blood will be collected to assess parameters related to the outcome measures | Baseline, 3 months and 6 months |
| Dietary intake | Baseline, 3 months and 6 months |
| Physical performance | Baseline, 3 months and 6 months |
| Cognitive performance | Baseline and 6 months |
| Blood pressure | Baseline, 3 months and 6 months |
| Physical activity | Baseline, 3 months and 6 months |
Countries
Netherlands
Outcome results
None listed