Sarcopenia
Conditions
Keywords
sarcopenia, frail elderly, protein drink, skeletal muscle mass, muscle mass in elderly
Brief summary
The present study is designed to investigate whether timed protein supplementation will increase skeletal muscle mass in the frail elderly population.
Interventions
DIETARY_SUPPLEMENTProtein drink
Twice a day during 6 months
DIETARY_SUPPLEMENTPlacebo drink
Twice a day during 6 months
Sponsors
Maastricht University Medical Center
Top Institute Food and Nutrition
Wageningen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Frail elderly individuals * Able to understand and perform the study procedures
Exclusion criteria
* Type I or type II diabetes (fasted blood glucose level ≥7,0 mmol) * No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire) * Use of anti-coagulation medication (except of Acetyl Salicyl acid) * Renal insufficiency (eGFR \<60 mL/min/1.73 m2) * Allergic or sensitive for milk proteins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in skeletal muscle mass | Baseline, 3 months and 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Blood parameters related to the outcome measures | Baseline, 3 months and 6 months |
| Dietary intake | Baseline, 3 months and 6 months |
| Physical performance | Baseline, 3 months and 6 months |
| Cognitive performance | Baseline and 6 months |
| Blood pressure | Baseline, 3 months and 6 months |
| Physical activity | Baseline, 3 months and 6 months |
Countries
Netherlands
Outcome results
None listed