Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction

Conditions

Myocardial Infarction

Keywords

aldosterone, myocardial infarction, cardiac remodeling

Brief summary

This study aims to determine whether aldosterone blood levels are predictive of cardiac remodeling at 6 months following myocardial infarction with ST elevation (STEMI), independently of conventional predictive factors (size of myocardial infarction, age, hypertension, etc.) in revascularized patients during the acute phase of MI.

Detailed description

After myocardial infarction, the evolution toward cardiac failure is generally linked to a progressive worsening of cardiac dysfunction and remodeling. Cardiac remodeling is largely the consequence of myocardial injury due to myocardial infarction, although other parameters including age, arterial hypertension, etc. may also represent important predictors. Aldosterone blood levels measured within the first hours of admission for myocardial infarction is associated with increased rates of adverse outcomes. Aldosterone acts on wound healing and fibrosis processes in the myocardium as well as on systemic volemia.

Luca Monzo, Olivier Huttin, João Pedro Ferreira, Zohra Lamiral, Erwan Bozec et al. (13 authors)

European Journal of Heart Failure2023-08-0211 citations

10.1002/ejhf.2986

Cardiac remodeling following reperfused acute myocardial infarction is linked to the concomitant evolution of vascular function as assessed by cardiovascular magnetic resonance.

Huttin O, Mandry D, Eschalier R, Zhang L, Micard E, Odille F, Beaumont M, Fay R, Felblinger J, Camenzind E, Zannad F, Girerd N, Marie PY.

2017-01-0417 citations

10.1186/s12968-016-0314-6

Temporal deformation pattern in acute and late phases of ST-elevation myocardial infarction: incremental value of longitudinal post-systolic strain to assess myocardial viability.

Huttin O, Marie PY, Benichou M, Bozec E, Lemoine S, Mandry D, Juillière Y, Sadoul N, Micard E, Duarte K, Beaumont M, Rossignol P, Girerd N, Selton-Suty C.

2016-04-2321 citations

10.1007/s00392-016-0989-6

Interventions

BIOLOGICALblood sample

PROCEDUREMRI

PROCEDUREechocardiography

BIOLOGICALurine sample

PROCEDUREpulmonary echography

PROCEDUREvascular check

PROCEDURErenal echography

Study design

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Man or woman hospitalized for a first myocardial infarction with known shift of the segment ST revascularized in acute phase by primary angioplasty and dated less than 4 days * Patient presenting a stable clinical state * Patient presenting a regular sinusal cardiac rhythm * Patient having an age ≥ 18 years

Exclusion criteria

* Counter-indication with examination MRI * Severe claustrophobia * Antecedent of over-sensitiveness to gadolinium salts * Nonischaemic Cardiopathy * Cardiac surgery planed in the 6 months * Women into old to procreate without effective contraception

Design outcomes

Primary

Measure	Time frame
Cardiac remodeling within 6 months of myocardial infarction as defined as the change in left ventricle volumes (increase of more than 20 % of the diastolic volume of the left ventricle)	from initial assessment to 6 months

Secondary

Measure	Time frame
Vascular and cardiac parameters measured during the initial assesment and at 6 months (both functional and structural - by echocardiography or MRI)	from initial assessment to 6 months
Long-term cardiac remodeling measured by echocardiography at 3 to 9 years of initial enrollment	at 3 to 9 years of initial enrollment

Countries

France

Outcome results

None listed