Chronic Fatigue Syndrome, Fibromyalgia
Conditions
Keywords
Fibromyalgia, Chronic Fatigue Syndrome, D-ribose, fatigue
Brief summary
To determine whether adding Ribose 5 grams 3 x day would improve quality of life, energy, sleep and cognitive function and decrease pain in patients with CFS and/or fibromyalgia (CFS/FMS).
Detailed description
Chronic Fatigue Syndrome and Fibromyalgia (CFS/FMS) are debilitating syndromes affecting \ 2-4% of the population. Although they are heterogeneous conditions associated with many triggers, including infections, autoimmune illnesses, hormonal dysfunctions and other processes, they appear to have the common pathology of being associated with impaired energy metabolism. As D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle, and was shown to significantly improve clinical outcomes in CFS/FMS in an earlier pilot study, we conducted a larger, community based, multicenter trial to see if these findings could be generalized to a broader patient population. We hypothesized that giving D-ribose would improve function in CFS/FMS patients.
Interventions
DIETARY_SUPPLEMENTRibose
Ribose 5 grams PO TID was taken daily
Sponsors
Bioenergy Life Science, Inc.
Integrative Therapeutics, Inc.
Kona Research Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed with Fibromyalgia (FMS) (by American College of Rheumatology \[ACR\] criteria) and/or Chronic Fatigue Syndrome (CFS- by Centers for Disease Control \[CDC\] criteria) by a health practitioner.
Exclusion criteria
* pregnant or nursing women, or * any participants with known severe medication or nutrient sensitivities, or * previous ribose use.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total score of hedonic scale of 5 symptoms | Change in total score of 5 symptoms after 3 weeks of treatment | The assessed symptoms were energy, sleep, cognitive function, pain(inverse score) and overall sense of well being. Patients were asked to rate each of the 5 symptoms on a 1 to 7 scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total of change in hedonic scale | at 1 week of treatment | The assessed symptoms were energy, sleep, cognitive function, pain(inverse score) and overall sense of well being. Patients were asked to rate each of the 5 symptoms on a 1 to 7 scale |
| total change in hedonic scale | after 2 weeks of treatment | The assessed symptoms were energy, sleep, cognitive function, pain(inverse score) and overall sense of well being. Patients were asked to rate each of the 5 symptoms on a 1 to 7 scale |
| Side effects | 3 weeks | subjects and health practitioners were asked to report any side effects |
Countries
United States
Outcome results
None listed