Comparison of 5 Day Embryo Transfer With 2-3 Day Transfer in Patients With Previous In Vitro Fertilization Failure

Comparison of 5 Day Embryo Transfer With 2-3 Day Transfer in Patients Who Failed to Conceive in Two or More Day 2-3 Embryo Transfer Cycle in Royan Institute

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01107002

Enrollment

200

Registered

2010-04-20

Start date

2008-07-31

Completion date

2010-08-31

Last updated

2011-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

infertility, Embryo transfer

Brief summary

The purpose of this study is to determine whether embryo transfer on day 3 versus day 5 shows a significant difference in implantation, clinical pregnancy, live birth, miscarriage and multiple pregnancy rates among women with at least two previous IVF failures

Detailed description

A total of 200 infertile women with at least two previous IVF failures will enroll in this prospective randomized clinical trial study and will randomly be divided into two groups. Random permuted blocks with a block size of 4 will be used to ensure randomization and complete allocation concealment. The study protocol will be assessed by an independent institutional review board and Royan ethics committee. Ovarian stimulation protocol will include the use of a GnRH agonist (Superfact; Aventis Pharma Deutshlan, Frankfurt, Germany) administered in the long (down-regulation) protocol and the subsequent addition of FSH (Gonal F, Sereno, Switzerland). Embryos will be initially cultured in G1.V5 medium) Vitrolife-Sweden)TM on day 1 and 2, being transferred from this medium to G2.V5 ) Vitrolife-Sweden)TM on day 3. Embryos will be transferred on day 5, depending on the degree of expansion of the blastocyst. Main outcome measures will be implantation, clinical pregnancy and live birth rates.

Interventions

PROCEDUREDay 5 embryo transfer group

Embryo will transfer at blastocyst stage (day 5 after ovum pick up)

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Age fewer than 40 * Normal uterine cavity and patent tubes by either hysterosalpingogram or laparoscopy and hysteroscopy * Two previous or more failed IVF/ICSI cycles

Exclusion criteria

* Women with submucous myoma * Women with intra mural or subserous myoma greater than 3 cm * Women with Endometriosis or Endometrioma * Hydrosalpinx

Design outcomes

Primary

Measure	Time frame
Clinical Pregnancy rate	6-8 weeks after oocyte retrieval
Live birth rate	After 37 weeks of gestational age

Secondary

Measure	Time frame
Implantation rate	4 weeks after embryo transfer
Miscarriage rate	18 weeks after fertilization

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026