Factor XIII and Pulmonary Embolism in Neurosurgical Patients

Risk Factors for Perioperative Pulmonary Embolism in Neurosurgical Patients in Respect of Factor XIII Activity

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01106937

Enrollment

130

Registered

2010-04-20

Start date

2007-10-31

Completion date

2010-12-31

Last updated

2010-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Tumor, Factor XIII Deficiency, Pulmonary Embolism, Vascular Lesion

Brief summary

Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy. Since then, factor XIII is measured and substituted in various centers. Few reports support the idea of factor XIII being involved in the formation of deep venous thrombosis and pulmonary embolism. In this prospective observational study, patients undergoing craniotomy for brain tumors or vascular lesions are investigated concerning the incidence of postoperative pulmonary embolism in respect of possible risk factors (factor XIII activity levels, standard coagulation parameters, tumor entity, blood loss).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* preoperatively low Factor XIII activity * neurosurgical procedure (craniotomy) * substitution of Factor XIII * postoperative occurence of pulmonary embolism

Design outcomes

Primary

Measure	Time frame
Incidence of pulmonary embolisms following Factor XIII substitution	38 months

Countries

Germany

Contacts

Primary ContactStefan Grau, Dr.

stefan.grau@med.uni-muenchen.de+4989/7095-0

Outcome results