Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain

A Randomized Controlled Trial Comparing Coronary CT Angiography and Radionuclide Stress Myocardial Perfusion Imaging in Symptomatic Inpatients With Known Coronary Artery Disease

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01106612

Acronym

PROSPECT-CAD

Enrollment

Registered

2010-04-20

Start date

2010-04-30

Completion date

2013-12-31

Last updated

2015-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Angina Pectoris, Unstable Angina, Acute Coronary Syndrome

Keywords

randomized controlled trial, controlled clinical trial, comparative effectiveness research, chest pain, angina pectoris, non-invasive cardiac imaging, nuclear stress testing, coronary CT angiography, coronary catheterization, coronary revascularization

Brief summary

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with known coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Interventions

PROCEDURECoronary CT angiography

EKG-gated, computed tomography angiography of the coronary arteries during heart rate control

PROCEDUREMyocardial perfusion imaging

Stress radionuclide myocardial perfusion imaging

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient admitted for chest pain / pressure or other suggestive symptoms * patient has known coronary artery disease (with or without prior revascularization) * patient has clinical need for non-invasive cardiac evaluation

Exclusion criteria

* evidence of ongoing myocardial infarction or hemodynamic instability * ischemia on EKG (greater than 1mm ST segment deviation) * contraindications to CT scanning with iodinated intravenous contrast (including allergies, asthma and renal dysfunction) * heart rhythm precluding EKG gating * pregnancy

Design outcomes

Primary

Measure	Time frame
Number of participants that undergo subsequent cardiac catheterization but do not have consequent coronary angioplasty, stenting or bypass	3 months

Secondary

Measure	Time frame
Length of hospital stay (time to discharge)	1 month
Number of participants that have a subsequent non-fatal myocardial infarction	1 year
Number of participants that die due to any cause	1 year
Number of participants that experience a procedural complication due to non-invasive imaging, cardiac catheterization or coronary revascularization	3 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026