Total Knee Arthroplasty
Conditions
Keywords
Adductor-Canal-Blockade, postoperative pain, US-guided nerve block, total knee arthroplasty
Brief summary
The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing morphine consumption and pain, and at the same time improving mobilisation after total knee arthroplasty.
Interventions
PROCEDUREAdductor-Canal-Blockade
US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml
PROCEDUREAdductor-Canal-blockade with saline
US-guided Adductor-Canal-blockade with saline
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Total Knee Arthroplasty in spinal anaesthesia * ASA 1-3 * BMI 18-40 * Written informed consent
Exclusion criteria
* Can not cooperate to the exam * Do not speak or understand Danish * Drug allergy * Alcohol or drug abuse * Daily consumption of strong opioids * Unable to complete the Timed Up and Go test preoperatively
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total morphine consumption | 0-24 hours postoperative | Total morphine consumption at the interval 0-24 hours postoperative. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain during rest | 0-26 hours postoperative | 0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative. |
| Pain during 45 degrees active flexion of the knee | 0-26 hours postoperative | 0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative. |
| A change in pain in the placebo group | 24-26 hours postoperative | 0-100 mm at a visual analogue scale (VAS), at the intervals 24 and 26 hours postoperative. |
| Postoperative nausea | 0-26 hours postoperative | Nausea scores(0-3)at 2,4,8,24,26 hours postoperative. |
| Total morphine consumption | 0-26 hours postoperative | Total morphine consumption at the intervals 0-2, 0-4, 0-8 and 0-26 hours postoperative. |
| Sedation | 0-26 hours postoperative | Seadtion score (0-3) at 2,4,8,24,26 hours postoperative. |
| Mobilisation | 20-26 hours postoperative | Number of seconds it takes to complete the Timed Up and Go test, at 20 and 26 hours postoperative. |
| Postoperative vomiting | 0-26 hours postoperative | Number of vomiting episodes at the intervals 0-2,2-4,4-8,8-24,24-26 hours postoperative. |
| Zofran consumption | 0-26 hours postoperative | Total zofran consumption at the intervals 0-24 and 24-26 hours postoperative. |
Countries
Denmark
Outcome results
None listed