Nutrition, Growth and Development Among Very Preterm Infants

Conditions

Low Birth Weight Infant

Keywords

VLBW, nutrition, vitamin A, long-chain unsaturated fatty acids, growth, cognitive functions, Very low birth weight infants (birth weight below 1,500 grams).

Brief summary

The main purpose of this study is to evaluate the effect of increased supply of energy, protein, vitamin A and the long chain polyunsaturated fatty acids docosahexaenoic acid and arachidonic acid on growth, brain maturation and cognitive function.

Strømmen K, Haag A, Moltu SJ, Veierød MB, Blakstad EW, Nakstad B, Almaas AN, Brække K, Rønnestad AE, Daniel H, Drevon CA, Iversen PO.

2017-02-1313 citations

10.1016/j.clnesp.2017.01.003

Increased levels of phthalates in very low birth weight infants with septicemia and bronchopulmonary dysplasia.

Strømmen K, Lyche JL, Blakstad EW, Moltu SJ, Veierød MB, Almaas AN, Sakhi AK, Thomsen C, Nakstad B, Brække K, Rønnestad AE, Drevon CA, Iversen PO.

2016-02-2620 citations

10.1016/j.envint.2016.01.024

Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants

Elin W. Blakstad, Sissel J. Moltu, Britt Nakstad, Marit B. Veierød, Kenneth Strømmen et al. (11 authors)

Food & Nutrition Research2016-01-0111 citations

10.3402/fnr.v60.33171

Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia--a randomized, controlled trial.

Moltu SJ, Strømmen K, Blakstad EW, Almaas AN, Westerberg AC, Brække K, Rønnestad A, Nakstad B, Berg JP, Veierød MB, Haaland K, Iversen PO, Drevon CA.

2012-09-21114 citations

10.1016/j.clnu.2012.09.004

Interventions

DIETARY_SUPPLEMENTNutrition

The control (placebo) group will be fed according to the routines of the participating institutions. The intervention (active) group will receive increased supply of energy, protein, vitamin A and long-chain unsaturated fatty acids.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

No

Inclusion criteria

* Birth weight below 1,500 grams * Written consent to participate from the parents

Exclusion criteria

* Congenital malformations * Clinical syndromes known to affect growth and development * Critical illness and short life expectancy * If participants refuse to participate

Design outcomes

Primary

Measure	Time frame	Description
Reduction in discharge rate of small-for-gestational age very low birth weight infants	6 months corrected age	The primary endpoint is to reduce the discharge rate of very low birth weight infants that are small-for-gestational age, from 60 to 40%.

Secondary

Measure	Time frame	Description
Evaluation of brain function and growth of infant	6 months corrected age	Secondary endpoints will include: 1. Assessment of brain maturation using MRI. 2. Cognitive measurements. 3. Anthropometric measures and biomarkers to assess body growth and development. 4. Morbidity- (e.g. ROP, BPD, PVL, NEC) and mortality rates.

Countries

Norway

Outcome results

None listed