Osteomalacia
Conditions
Keywords
fibroblast growth factor 23, Osteomalacia, vitamin D
Brief summary
We aimed to determine the effect of vitamin D replacement therapy on serum FGF-23 concentrations in vitamin D deficient women and to compare the FGF-23 concentrations of vitamin D deficient patients with healthy subjects and patients with genetically-determined hypophosphatemic rickets.
Detailed description
Study group was composed of vitamin D deficient females (n =18, mean age 29.1±9.9 yrs), vitamin D sufficient healthy females (control group; n = 19, mean age 28.5±5.2 yrs) and patients with genetically-determined hypophosphatemic rickets (n=13, mean age 26.5±15.1 yrs). Groups were compared for serum FGF-23, 1,25 dihydroxy vitamin D3, calcium, phosphate, bone turnover markers, intact parathyroid hormone and urinary excretion of calcium and phosphate. Vitamin D deficient group was re-evaluated after a standard treatment regimen.
Interventions
None listed
Sponsors
Istanbul University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
9 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Serum 25OHD Vitamin \<30 ng/mL for group 1 * Serum 25OHD Vitamin \>30 ng/mL for control group
Exclusion criteria
* Receiving medication(s) affecting bone metabolism * History of gastrointestinal disease and malabsorption * History of renal and liver disease
Countries
Turkey (Türkiye)
Outcome results
None listed