Hearing Loss
Conditions
Keywords
hearing loss, head and neck cancer, radiotherapy, hearing complaint, Hearing loss due to the exposure of radiotherapy
Brief summary
Hypothesis: Treatment for head and neck tumors often involve methods that affect the auditory system and cause hearing loss. Neck dissection negatively impacts the lymphatic drainage, chemotherapy uses ototoxic drugs, radiotherapy affects blood flow and tissue radiation is toxic to the ear and may lead to hearing losses of various types and degrees. Objective: To investigate occurrences of hearing loss and complaints among patients with head and neck tumors who underwent radiotherapy. Study design: Prospective, case-control study. Setting: Tertiary care center hospital. Subjects and Methods: 282 subjects were evaluated, 141 with head and neck tumors and 141 as an age-matched control group. The controls had never undergone oncological treatment that put their hearing at risk. All subjects underwent audiological evaluation, including the HHIE questionnaire, pure tone audiometry, speech audiometry and immittance audiometry. The radiation dose received by the auditory system was calculated based on the percentage of the external auditory canal included in the radiation field.
Interventions
None listed
Sponsors
Hospital A.C. Camargo
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
11 Years to 84 Years
Healthy volunteers
Yes
Inclusion criteria
* The group of exposed individuals * had to be patients with disease-free survival interval of at least two years subsequent to treatment for head and neck cancer * radiotherapy alone or in combination, in which the auditory system was included in the field of irradiation. * The group of non-exposed individuals (control group) * had to be patients who had not undergone oncological treatment that put their hearing at risk * age-matched (2 years). This group was formed by individuals who had had pelvic tumors or skin tumors and who had only undergone local surgery to remove their tumors, and by female volunteers from the hospital. * All of these individuals were asked whether they would be willing to participate in a study, without knowing in advance whether they had any previous hearing problems or complaints.
Exclusion criteria
* congenital hearing loss * otological surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The hearing loss was evaluated through conventional tone threshold audiometry and a questionaire of hearing handicap was applied to both groups (individuals exposed to radiotherapy and the control group). | patientes were evaluated two years after finished the treatement | We observed mild to moderate hearing losses at frequencies of 57.4% in right ears and 59.6% in left ears in the group exposed to radiotherapy and in the control group, 43.3% ofmild to moderate hearing loss in both ears.Severe or profound hearing losses or anacusis occurred at frequencies of 6.4% in right ears and 8.5% in left ears, versus only 1.4% in the control group.Furthermore, severe handicap was observed in 2.8% of the individuals in the control group, versus 19.1% in the group exposed to radiotherapy. |
Countries
Brazil
Outcome results
None listed