Elastography in Thyroid Nodules

Accuracy of Ultrasound Elastastography in Thyroid Nodular Disease.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01102127

Enrollment

128

Registered

2010-04-13

Start date

2010-02-28

Completion date

2010-09-30

Last updated

2011-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nodular Goiter, Thyroid Cancer

Keywords

elastography, thyroid nodule, fine-needle aspiration

Brief summary

Nodular goiter is a highly prevalent disease in iodine-deficient areas. Usually nodule assessment includes ultrasonography (US) and fine-needle aspiration (FNA), but some benign nodules can hardly be distinguished from carcinomas. Elastography measures tissue elasticity using sonography, as malignancy is related to stiffness of solid organs. The investigators have designed a study to evaluate the diagnostic accuracy of elastography in nodular goiter. Consecutive patients will be assessed using US, FNA and elastography; the latter will be compared with cytology. Specificity, sensitivity, and predictive values will be calculated.

Detailed description

Aims: Primary aim: to evaluate the diagnostic accuracy of elastography in thyroid nodules from a low-risk of thyroid cancer population. Secondary aim: to evaluate the usefulness of elastography to detect carcinomas in thyroid nodules with indeterminate FNA. Patient selection: Inclusion criteria: * Age \> 18 yr. * Recruitment in Endocrinology Clinics. * Nodular goiter. * Multinodular goiter with dominant nodule \> 1 cm. Exclusion criteria: * Toxic nodules * Non-accessible nodules to US or FNA * Cystic nodules * Nodules with calcifications in egg rind * Contraindication for FNA

Interventions

DEVICEElastography

Performance of US, elastography and FNA.

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 yr. * Recruitment in Endocrinology surgery. * Nodular goiter. * Multinodular goiter with dominant nodule \> 1 cm.

Exclusion criteria

* Toxic nodules * Non-accessible nodules to US or FNA * Cystic nodules * Nodules with calcifications in egg rind * Contraindication of FNA

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic accuracy of elastography for thyroid cancer	1 day	Sensitivity, specifity, predictive values

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026