Major Depressive Disorder
Conditions
Keywords
Limbic surgery, Stereotactic surgery, Major Depressive Disorder: Treatment Refractory
Brief summary
This study will report on the outcome of a clinical program, operational since 1998, that has used surgery targeting an emotional pathway in the brain in the treatment of severe depressive illness that has failed to respond to all other available interventions. Benefit from surgery was anticipated on the basis that the lesion (bilateral anterior capsulotomy) is a well established surgical target for treating severe treatment resistant depression.
Detailed description
Since 1998 bilateral anterior capsulotomy (BAC) has been available to patients in British Columbia Canada who have treatment refractory severe depressive illness. This study will report on the outcome of patients who have received this intervention. BAC is achieved by stereotactic radiofrequency lesioning. To date 8 patients have received BAC. For all patients there is follow-up data of at least 24 months. The purpose of this retrospective study is to report on the surgical protocol and to demonstrate the efficacy and safety of BAC in severe depression.
Interventions
None listed
Sponsors
University of British Columbia
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Severe treatment resistant depression of at least 5 years duration * older than 18 years
Exclusion criteria
* Comorbid organic mental disorder * Delusional disorder * Substance disorder * Neurological disease * Cluster B personality disorder
Countries
Canada
Outcome results
None listed