Healthy
Conditions
Brief summary
Populations that report high fiber consumption demonstrate lower rates of obesity. Enhanced satiety may play a key role in this relationship. The colonic fermentation of fibers is theorized to influence satiety and food intake. Short chain fructooligosaccharide (scFOS) are rapidly fermentable fibers that can easily be added to foods to impact these parameters. The objective of this study was to evaluate the satiety response of scFOS and its ability to decrease food intake.
Detailed description
Intervention study with fiber added to beverages and acute effects on satiety measured.
Interventions
DIETARY_SUPPLEMENTShort chain fructo-oligosaccharide (scFOS) 5 g
Dietary Supplement: scFOS 5 g Novel fiber administered in two 5 g doses--the first in a beverage and the second in a solid chew.
OTHERPlacebo
Treatment without scFOS fiber
DIETARY_SUPPLEMENTShort chain fructooligosaccharide (scFOS) 8 g
Novel fiber administered in two 8 g doses--the first in a beverage and the second in a solid chew.
Sponsors
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women * Age 18-64 years * Non-smoking * Not taking medication * Non-dieting (weight stable in prior 3 months) * BMI 18-27 * English literacy
Exclusion criteria
* Do not regularly consume breakfast * Food allergies to ingredients found in study products * BMI \<18 or \>27 * Diagnosed cardiovascular, renal, or hepatic disease diabetes mellitus * Cancer in previous 5 years (except basal cell carcinoma of the skin) * Any gastrointestinal disease or condition * Recent bacterial infection (\< 3 months) * Recent or concurrent participation in an intervention research study * History of drug or alcohol abuse in prior 6 months * Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication * Eating disorder * Vegetarians * People who eat more than approximately 15 grams of fiber per day * Women who are pregnant or lactating * Women with irregular menstrual cycles
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Satiety response using visual analogue scales | 0, 15, 30, 45, 60, 90, 120, 180, 240 minutes postprandially | Satiety response was measured using subjective perceptions of hunger, fullness, satisfaction, and prospective food intake evaluated by previously validated visual analogue scales (VAS). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ad libitum food intake | 240 minutes postprandially and over 24 hours | — |
| Breath hydrogen response | 0, 240 minutes | — |
| Gastrointestinal tolerance using visual analogue scales (VAS) | 24 hours | Subjective ratings of bloating, stool consistency, and flatulence on VAS. A stool count was also recorded. |
Countries
United States
Outcome results
None listed