Atherosclerosis
Conditions
Keywords
atherosclerosis, vascular inflammation, MDCT, 18FDG-PET
Brief summary
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.
Interventions
OTHERCross section study
This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting
Sponsors
Korea University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy patients for visiting routine medical check in our clinic
Exclusion criteria
* History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization) * Diabetes * Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg) * Malignancy * Severe renal or hepatic disease * Subjects taking medications that might affect inflammation such as NSIAD and statin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between vascular inflammatory status measured by 18FDG PET and MDCT | 20weeks |
Secondary
| Measure | Time frame |
|---|---|
| Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT | 20 weeks |
Countries
South Korea
Outcome results
None listed