Low Grade Inflammation in Type 1 Diabetes Children

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01099956

Acronym

Coccinelle

Enrollment

Registered

2010-04-08

Start date

2010-04-30

Completion date

2010-07-31

Last updated

2011-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Type 1 Diabetes

Keywords

type 1 diabetes, children, low grade inflammation, cytokine, CRP

Brief summary

The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.

Detailed description

The increase of type 1 diabetes incidence, particularly in young children leads to conduce new diagnostic and therapeutic strategies, notably for associated chronic morbidity.Measurement of chronic inflammation, with modification of the balance between pro-inflammatory cytokines and anti-inflammatory cytokines, could lead to detect patients with high risk to diabetes chronic morbidity. After parental consent, blood sampling will be carried out by micromethod for cytokine (500 µl) and CRPhs dosages and glycemia (100 µl) and glycated hemoglobin (1 µl). Urine will be collected (50 ml) in the morning for further researches.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

2 Years to 17 Years

Healthy volunteers

Yes

Inclusion criteria

Type 1 diabetes children group : * Children aged 2 to 17 years * Type 1 diabetes children Controlled group : * Children aged 2 to 17 years * Brother or sister of type 1 diabetes children

Exclusion criteria

* Per os or inhaled corticoid in the previous month of inclusion * Acute infectious disease in the previous week of inclusion * Other chronic disease than diabetes type1

Design outcomes

Primary

Measure	Time frame
Increase of Interleukine 6 in group DTI versus control group	Once at inclusion

Secondary

Measure	Time frame
Increase of others cytokines (IL1-beta, l'IL-4, l'IL-10 and TNF alpha) and increase of High sensitivity CRP in group DTI versus control group	Once at inclusion

Countries

France

Outcome results