Fever
Conditions
Keywords
fever, Ibuprofen
Brief summary
Ibuprofen, the active ingredient in Nurofen and Advil, is a commonly used drug in children. There is very limited data about Ibuprofen concentrations in the cerebro spinal fluid (CSF). The objective of the current study is to describe concentrations of ibuprofen in the CSF of infants and children after administration of ibuprofen. We will study infants presenting to the Emergency Department (ED) with fever who received ibuprofen. A complete sepsis workup including sampling of blood and CSF is conducted in cases of suspected meningitis. We will measure ibuprofen in the blood and CSF obtained during the sepsis workup. A better understanding of the pharmacokinetics of ibuprofen and its penetration into the CSF will unable us to suggest more accurate dosing guidelines, and to better predict the effects of this commonly used drug.
Interventions
DRUGIbuprofen
Ibuprofen (10mg/kg BW) will be given orally if the temperature on presentation is higher than 38.0OC according to the decision of the attending physician.
Sponsors
Assaf-Harofeh Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Age: 3 month-18 years * Rectal temperature \> 38.0OC or oral temperature \> 37.6 OC measured in the ED or at home. * A sepsis work up is indicated * At least one dose of Ibuprofen was given in the last 8 hours prior to lumbar puncture (LP)
Exclusion criteria
* Hypersensitivity to Ibuprofen * Known metabolic disorder * Known liver or kidney disease * Hydrocephalus * Informed consent could not be obtained from a legal guardian
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ibuprofen concentration in the CSF | 30 - 360 minutes after administration |
Countries
Israel
Contacts
Primary ContactEran Kozer, MD
Outcome results
None listed