Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01098773

Acronym

PULCO

Enrollment

100

Registered

2010-04-05

Start date

2010-02-01

Completion date

2010-12-01

Last updated

2026-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Patients Ventilated More Than 48 h, Arterial Line, Consent of Patients, Stable Respiratory and Hemodynamic Conditions for SBT

Keywords

Weaning from mechanical ventilation, BNP, Lung ultrasound, Echocardiography

Brief summary

Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.

Detailed description

Prospective observational clinical multicentric study on ICU ventilated patients requiring chest ultrasound analysis during weaning from mechanical ventilation with 48 hours of follow-up. Studying variations of cardiac markers

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Adult patients ventilated more than 48 h * Stable respiratory and hemodynamic conditions for SBT * Consent of patients * Arterial line

Exclusion criteria

* Laryngeal dyspnea * Tracheostomy * Arythmya * No echogenicity * Paraplegia \>T8

Design outcomes

Primary

Measure	Time frame	Description
Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.	before, at the end, and 4-6 h after	Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.

Secondary

Measure	Time frame	Description
Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP.	in the 4-6 early hours	Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP.
Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours.	in the 4-6 early hours.	Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours.
Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT.	in the 4-6 early hours	Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT.
Comparison of levels epithelial and endothelial markers	at h0, h1, h4, h6	—
Constitution serum bank for epithelial (sRAGE) markers dosages	at h0, h1, h4, h6	—
constitution serum bank for endothelial (angiopoietin) markers dosages	at h0, h1, h4, h6	—

Countries

France

Contacts

PRINCIPAL_INVESTIGATORSébastien PERBET

University Hospital, Clermont-Ferrand

Outcome results