Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum

Determination of the in Vitro Effects of CALM on COPD Sputum

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01096173

Enrollment

Registered

2010-03-30

Start date

2010-04-30

Completion date

2010-10-31

Last updated

2011-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Sputum, chronic obstructive pulmonary disease

Brief summary

This study is intended to be an evaluation of the properties of human sputum collected from patients with COPD. It is hypothesized that cationic airway lining modulators will have beneficial effects on the rheological properties of sputum derived from patients with COPD. Approximately 10 patients with COPD will collect sputum at home for 5 days. Samples will be collected and tested in laboratory tests.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

35 Years to 90 Years

Healthy volunteers

Inclusion criteria

1. Clinical and spirometric diagnosis of COPD 2. Smoking history of at least 10 pack yrs 3. Sputum production of greater than 2 tablespoons per day by patient report.

Exclusion criteria

1. a primary diagnosis of asthma or bronchiectasis 2. a COPD exacerbation within 4 weeks 3. Inability to comply with study procedures.

Countries

United States

Outcome results