Pain
Conditions
Keywords
Pain after treatment, healing of fissure after treatment, continence scores after treatment
Brief summary
Intra-sphincteric injection of botulinum toxin seems to be a reliable option causing temporary alleviation of sphincter spasm and allowing the fissure to heal. study is to compare the outcome of surgical sphincterotomy and botulinum toxin injection treatments in patients with uncomplicated chronic anal fissure.
Detailed description
consecutive patients with uncomplicated chronic anal fissure who had failed conservative treatment were randomized to receive either intra-sphincteric injection of botulinum toxin (BT) or lateral internal sphincterotomy (LIS). Postoperative pain relief, healing of fissure, continence scores and fissure relapse during 18 weeks of follow up was the outcomes assessed.
Interventions
PROCEDUREconservative lateral internal sphincterotomy
PROCEDUREIntra-sphincteric Botulinum-toxin injection
Sponsors
Theodor Bilharz Research Institute
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* The diagnosis of chronic anal fissure was based on evidence of circumscribed ulcer at anal canal with indurations at the edges and exposure of the horizontal fibers of the internal anal sphincter at its floor.
Exclusion criteria
* Anal fissure that had been operated on before, complicated fissure with cicatricial deformation, large sentinel pile, associated hemorrhoids, suspected inflammatory bowel disease, or malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain relief, healing of fissure, continence scores | 18 weeks |
Secondary
| Measure | Time frame |
|---|---|
| fissure relapse | 18 weeks |
Countries
Egypt
Outcome results
None listed