Periodontitis, Chronic Kidney Disease
Conditions
Brief summary
The purpose of this study is to examine the role of gum disease in affecting the long term prognosis of renal patients. This disease if untreated causes inflammatory response throughout the body. If the subject has gum disease, he/she will be randomly assigned to one of the two treatment groups. The study investigates what happens to inflammatory markers in blood and saliva after you are treated for gum disease.
Detailed description
The main goal of this project was to explore the contribution of chronic periodontitis to systemic inflammation in Chronic Kidney Disease (CKD). To achieve this goal, the project had two specific objectives: 1. a) To compare the prevalence of periodontal infection between CKD and non-CKD populations and b) to explore the association between the presence of periodontal infection and the uremic status of CKD patients. 2. a) To assess the levels of systemic inflammatory markers, IL-6 and CRP in the presence or absence of periodontal infection in CKD and b) to compare the serum IL-6 and CRP levels in response to periodontal intervention.
Interventions
PROCEDUREScaling root planing
Deep gum cleaning with local anesthesia
PROCEDURESupragingival Prophylaxis
Plaque removal
Sponsors
National Institute of Dental and Craniofacial Research (NIDCR)
UConn Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* dental subjects with periodontitis, * at least 10 teeth * no periodontal (gum) treatment for the last year, * no antibiotic for the last 4 months, * no vascular access infection.
Exclusion criteria
* smokers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum Interleukin-6 (IL-6) and C-reactive protein (CRP) levels | 2 months | IL-6 and CRP are markers of systemic inflammation and may improve at the end of gum treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in periodontal (gum) clinical presentation and status | 2 months | For the secondary outcome, periodontal variables such as bleeding on probing, probing depth (the depth of the gum sulcus around the tooth), and bacterial plaque score will be evaluated to assess the effectiveness of the intervention and the compliance of the patients |
Countries
United States
Outcome results
None listed