To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure

To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure, and if This Effect is Mediated in Gastroesophageal Reflux Disease (GERD)Patients by Altering Appetite Regulation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01093339

Acronym

IRUSESOM0428

Enrollment

Registered

2010-03-25

Start date

2006-08-31

Completion date

2010-03-31

Last updated

2010-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal Disease

Keywords

GERD, SLEEP DEPRIVATION, APPETITE REGULATION, GHRELIN, LEPTIN

Brief summary

The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.

Detailed description

To determine if increased esophageal acid exposure is mediated by altering appetite regulation. To assess if there is any relationship between sleep deprivation and the serum level of TNF-alfa (a protein that can be elevated in inflammation).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Male/Female - 18-80 * 2 or more episodes of heartburn a week for last 3 months

Exclusion criteria

* Previous upper GI surgery * Underlying co-morbidity * Narcotic medications * Psychotropic's and Benzodiazapines medications * Hx of psychological abnormalities * Hx of ETOH in previous 6 mos. * Diabetes Mellitus * Neuropathy * Seizures * Sleep Apnea * Co-morbidity that interfere w/sleep * Women who are pregnant, or childbearing yrs, not on BC

Countries

United States

Outcome results