Endometriosis
Conditions
Keywords
Endometrioma recurrence, oral contraceptives, gonadotropin-releasing hormone agonist
Brief summary
Ovarian endometriotic cyst (endometrioma) is one of the most common endometriotic lesions, and conservative laparoscopic surgery is the treatment of choice. However, the recurrence after surgery is common. As repetitive surgery leads to morbidities and ovarian function decrease, recurrence after surgery frustrates both patients and clinicians. In this aspect, medical treatments have been offered after surgery to prevent or delay the recurrence. Gonadotropin-releasing hormone agonist (GnRHa) is frequently used in women with advanced endometriosis, but the efficacy is rather controversial. On the other hand, it has been demonstrated that oral contraceptives (OCs) could reduce or delay endometrioma recurrence, but data are still limited. Consequently, no one type of postoperative medical therapy has been shown to be superior in reducing the recurrence of endometrioma. The rationale of postoperative medical therapy is that it could eradicate microscopic lesions which were not found and not treated sufficiently during surgery. Therefore, the maintenance of strongly suppressed condition induced by postoperative GnRHa treatment by addition of OCs could be a promising treatment to prevent the recurrence, but it has not been widely investigated. We performed this retrospective cohort study to evaluate the efficacy of cyclic monophasic low-dose OCs as a maintenance therapy after GnRHa treatment for the suppression of endometrioma recurrence.
Interventions
None listed
Sponsors
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
15 Years to 49 Years
Healthy volunteers
No
Inclusion criteria
1. reproductive aged women who underwent conservative laparoscopic ovarian surgery for endometrioma (ASRM stage III/IV) which was confirmed by pathologic inspection 2. women who were given postoperative GnRHa injections every 28 days for 3 or 6 months 3. women with no residual lesion confirmed by ultrasonography after surgery 4. women who were followed up for over 12 months after surgery.
Exclusion criteria
if they had 1. undergone hysterectomy during an operation 2. been given GnRHa injections more than 6 times 3. been given other types of postoperative treatment (progestin or intrauterine device) 4. a history of previous pelvic surgery for endometriosis 5. a history of hormonal treatment before surgery 6. been diagnosed as menopause after surgery 7. contraindications to OCs 8. been identified ovarian endometriomas within 6 months of postoperative evaluation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence rate of endometrioma | 60 months |
Countries
South Korea
Contacts
Primary ContactDooSeok Choi, MD, PhD
Outcome results
None listed