Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness

Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect-site Concentration for Loss of Consciousness

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01091350

Enrollment

Registered

2010-03-24

Start date

2009-05-31

Completion date

2009-11-30

Last updated

2013-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anesthesia

Brief summary

The aim of this study is to validate that an effect compartment concentration for loss of consciousness (LOC) was varied according to different Keo value.

Interventions

DEVICEDiprifusor (Target-controlled infusion)

Two TCI devices with different Teo and same Marsh PK model

DEVICEOrchestra (Target-controlled infusion)

Two TCI devices with different Teo and same Marsh PK model

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Adult patients undergoing general anesthesia

Exclusion criteria

* Hepatic or renal disease * Drug addiction

Design outcomes

Primary

Measure	Time frame
Estimated effect-site propofol concentration at loss of consciousness	after propofol infusion

Secondary

Measure	Time frame
Time to loss of consciousness	after propofol infusion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026