Localizing the Epileptogenic Zone With High Resolution Electroencephalography

Etude de la Performance Diagnostique de l'EEG-Haute Résolution Sur la Localisation de la Zone épileptogène Pour le Traitement Chirurgical Des épilepsies Partielles Pharmaco-résistantes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01090934

Acronym

EEG-HR

Enrollment

115

Registered

2010-03-23

Start date

2009-10-31

Completion date

2013-11-30

Last updated

2016-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Partial Epilepsy

Keywords

Diagnosis, Partial Epilepsy

Brief summary

Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.

Interventions

DEVICEHigh Resolution EEG

High Resolution EEG

DEVICEStereo-electroencephalography

SEEG

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

* medically intractable patial epilepsy confirmed by video-EEG recordings of epileptic seizures. * Depth EEG (Stereo-EEG) required to delineate the epileptogenic zone and define the surgical procedure. * full informed consent of the patient (or of his/ her legal representative) * 15 year or older patient

Exclusion criteria

* contraindication to cortectomy * contraindication to depth-EEG * indication of epilepsy surgery without depth-EEG monitoring * high grade glioma, arterio-veinous malformations * pregnancy * history of severe cardio-vascular event (coronaropathy, stroke)

Design outcomes

Primary

Measure	Time frame	Description
Sensitivity and specificity of electrical source localization of inter-ictal and ictal discharges using high-Resolution EEG for localizing the epileptogenic zone (the stereo-electroencephalography will be the reference method)	3 years	results of electrical sources localization of inter-ictal and ictal discharges are compared to the epileptogenic zone defined by SEEG

Secondary

Measure	Time frame	Description
inter-observer reliability of electrical source localization of inter-ictal and ictal discharges for localizing the epileptogenic zone.	3 years	sources localization of inter-ictal and ictal discharges will be interpreted by two independant epileptologists, blinded to the results of stereo-EEG.
sensitivity and specificity of high resolution EEG and electrical source imaging for surgical decision	3 years	decision of surgery and the limits of the cortectomy established with electrical source imaging will be compared to the decision of surgery and the limits of the cortectomy established with Stereo-electroencephalography.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026