Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01090375

Enrollment

Unknown

Registered

2010-03-19

Start date

2008-08-31

Completion date

Unknown

Last updated

2010-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise, Osteoarthritis

Keywords

osteoarthritis, biochemical markers, cartilage, inflammation, microdialysis

Brief summary

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Interventions

OTHERExercise

OTHERNon Exercise

Study design

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Eligibility

Sex/Gender

FEMALE

Age

55 Years to 75 Years

Inclusion criteria

* verified osteoarthritis (x-ray)of the knee, female,

Exclusion criteria

* dementia, inflammatory diseases, regular pain medication

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 31, 2026