Healthy
Conditions
Brief summary
Coffee and green tea are 2 widely consumed beverages. Both contain polyphenol antioxidant compounds (chlorogenic acids for coffee and catechins for tea). The bioavailability of catechins is somewhat known and has been referenced in the literature. However, bioavailability data from tea infusion is non-existent, even though it reflects better how consumers drink this beverage. In addition, bioavailability of coffee chlorogenic acids is less understood and no dose response study has been reported so far in the literature. Thus, there is a great need to understand and reinforce our knowledge on the bioavailability of coffee and tea polyphenol compounds.
Interventions
OTHERGreen tea
Infusion (tea bags) from commercially available green tea
OTHERCoffee
Soluble coffee commercially available
Sponsors
Société des Produits Nestlé (SPN)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 - 65 years, male and female * Healthy as determined by the medical questionnaire and the medical visit * Normal weight: BMI 18 - 25 * Coffee drinkers with an average consumption of 2-5 cups per day * Having given informed consent
Exclusion criteria
* Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer * Have had a gastrointestinal surgery, except appendicectomy * Difficulty to swallow * Have a regular consumption of medication * Have taken antibiotic therapy within the last 6 months * Alcohol consumption \> 2 units a day * Smokers (more than 5 cigarettes per day) * Have given blood within the last 3 weeks * Volunteers who cannot be expected to comply with treatment * Currently participating or having participated in another clinical trial during the last 3 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare plasma Area under the curve (AUC) of highest and lowest dose of coffee for chlorogenic and phenolic acid metabolites | Measurements done over 24h after ingestion |
Secondary
| Measure | Time frame |
|---|---|
| Compare Area under the curve (AUC), Maximum plasma concentration (Cmax), Time to reach maximum plasma concentration (Tmax) and half-life (T1/2) of all three doses of coffee for chlorogenic and phenolic acid metabolites | Measurements done over 12h after ingestion |
| Compare AUC, Cmax, Tmax and T1/2 of all three doses of green tea for catechin metabolites | Measurements done over 12h after ingestion |
Countries
Switzerland
Outcome results
None listed