Astrocytoma, Oligoastrocytoma, Oligodendroglioma
Conditions
Keywords
Low grade glioma, Astrocytoma, Molecular imaging, FET PET, Therapy monitoring, Temodar
Brief summary
The aim of the study is to compare the two imaging modalities perfusion weighted MR-imaging and FET-PET in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within a homogeneously appearing tumor. Additionally, therapeutic effects should be assessed during a time period of two years.
Interventions
None listed
Sponsors
Deutsche Krebshilfe e.V., Bonn (Germany)
Ludwig-Maximilians - University of Munich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* neuroradiologically suspected low grade glioma (Astrocytoma WHOI-II, Oligodendroglioma WHO II, Oligoastrocytoma WHO II) * histological verification will be obtained either by microsurgery or by stereotactic biopsy * patients older than 18 years * Karnofsky Performance Score \>=70 * pregnant or nursing female patients will not be included in this study
Exclusion criteria
* patients in whom informed consent cannot be obtained due to organic brain syndrome or insufficient language skills * patients who cannot lie quiet for a time period of app. two hours during the FET-PEt scan * medical history of a metastatic brain disease * patients in whom an MRI scan cannot be performed due to claustrophobia metallic protheses or pacemakers etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival | 24 months |
Secondary
| Measure | Time frame |
|---|---|
| Progression Free survival | 24 months |
Countries
Germany
Outcome results
None listed