The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01089218

Enrollment

241

Registered

2010-03-18

Start date

2008-04-30

Completion date

2010-02-28

Last updated

2011-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fever, Pneumonia

Keywords

bronchoscopy, post-bronchoscopy fever, pneumonia, cytokines, amoxicillin/clavulanate, prophylaxis

Brief summary

Fever can develop after fiberoptic bronchoscopy (FB) in about 2.5 - 16 % of adult patients. We evaluated the impact of oral amoxicillin/clavulanate (AC) on incidence of postbronchoscopic fever and pneumonia.

Detailed description

For the population being undergone with bronchoscopy, the clinical signs and procedural measures for complication of bronchoscopy and cytokines will be checked.

Interventions

DRUGoral amoxicillin/clavulanate 1g (875/125mg)

oral amoxicillin/clavulanate 1g (875/125mg) on the day of the procedure 30 minutes prior to the FB

DRUGcontrol

no intervention with the same procedure of FB

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adult patients (aged 18 years or older) who underwent FB

Exclusion criteria

* concurrent treatment with antibiotics or systemic corticosteroid

Design outcomes

Primary

Measure	Time frame	Description
The incidence of fever	24 hr after bronchoscopy	time frame for body temperature 24hr before and after bronchoscopy every 4hrs

Secondary

Measure	Time frame	Description
change of serum cytokines level	before bronchoscopy and 24hr after bronchoscopy	Time frame for cytokine measurement 24hr before brochoscopy - 1hr after bronchosocpy - 24hr after brochoscopy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026