Pregnancy
Conditions
Keywords
vitrification, 2PN oocyte, maternal and infant health, embryo survival, clinical pregnancy rate, mode of delivery, injury during delivery, infant development, infant morbidity, slow- rate freezing
Brief summary
Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction. In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics. The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health. A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.
Interventions
OTHERObservation
Alberta infant motor scale Griffiths test Kauffmann ABC
Sponsors
University of Luebeck
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* cryopreservation (vitrification and slow- rate freezing) between 1998 - 2010 * Treatment in Lübeck University * Delivery in Lübeck University * Positive informed consent
Exclusion criteria
* Negative informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maternal pregancy outcome | 7 years | spontaneous or operative delivery, birth injuries, conjoined morbidity |
| embryo survival | 7 years | embryo survival rate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| infant health | 7 years | infant vital characteristics (APGAR, arterial cord ph), infant development: only develomental milestones: sitting, standing, walking infant morbidity |
Countries
Germany
Outcome results
None listed