Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery

The Correlation Between Certain Clock-gene Genotypes and POCD (Post-operative Cognitive Dysfunction)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01088100

Enrollment

279

Registered

2010-03-17

Start date

2010-08-31

Completion date

2011-01-31

Last updated

2011-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Genotype

Keywords

POCD, clock-gene genotypes, HPER3

Brief summary

The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.

Interventions

GENETICGenotyping

Determination of 3 types of clock gene genotypes (HPER 4/4, 5/4, 5/5) on all blood samples

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients undergoing non-cardiac and non-neurological surgery in either regional or general anesthesia

Exclusion criteria

* daily use of major tranquilizers or antipsychotic medication * known disease of the CNS * score less than 24/30 points in MMSE

Design outcomes

Primary

Measure	Time frame
HPER3 genotype	3 months

Secondary

Measure	Time frame
Post-operative morbidity	½ year

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 26, 2026