Stress Hyperglycemia. Potential Role of Incretin Analogs

Stress Hyperglycemia in Critically Ill Patients. Potential Role of Incretin Analogs. A Preliminary Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01087372

Enrollment

Registered

2010-03-16

Start date

2010-01-31

Completion date

2010-04-30

Last updated

2010-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness, Hyperglycemia

Keywords

Stress hyperglycemia, Incretins, GLP-1, GIP, glucoregulatory hormones

Brief summary

This is a prospective observational study to examine the levels of glucoregulatory hormones, with special focus on incretins levels, in critically ill patients with stress hyperglycemia.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Emergent ICU admission * Written informed consent from patient or relative.

Exclusion criteria

* Previously known type I or type II diabetes. * Patients who received insulin or oral antidiabetic agents before ICU admission. * Malignancies. * Scheduled surgery * Patients receiving enteral or parenteral nutrition. * Inability to obtain informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Incretins plasmatic levels	28 days	28 days and ICU mortality

Secondary

Measure	Time frame	Description
glucagon	28 days	28 days and ICU mortality
insulin	28 days	28 days and ICU mortality
cortisol	28 days	28 days and ICU mortality
HOMA index	28 days	28 days and ICU mortality

Countries

Spain

Outcome results