Objective Systolic Function Recuperation Assessed by Echocardiography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01086124

Acronym

ROSE

Enrollment

Registered

2010-03-12

Start date

2010-03-31

Completion date

2012-12-31

Last updated

2013-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Akinesis, Apical Akinesis, Left Ventricular Systolic Dysfunction, Myocardial Infarction

Keywords

echocardiography, ST elevation myocardial infarction, Heart failure, Coronary artery disease, Cardiovascular diseases

Brief summary

The purpose of this study is to evaluate left ventricular systolic ejection fraction and anterior or apical akinesis 1 month and 3 months after a myocardial infarction treated with primary PCI to determine whether improvement at 1 month differs from improvement at 3 months.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Older than 18 years old * ST elevation myocardial infarction treated with primary PCI * Anterior or apical akinesis and left ventricular ejection fraction ≤ 45% on early echocardiography (48hours - 7 days post myocardial infarction) * Initial ECG showing at least 1 mm ST elevation in 2 leads corresponding to the same vascular territory

Exclusion criteria

* Known left ventricular systolic dysfunction before myocardial infarction * Left bundle branch block * Vital prognosis less than 6 months * Cardiogenic shock * Rescue PCI * Sub-optimal echocardiographic imaging (contrast use is allowed) * Significant valvular heart disease (moderate or severe) * Surgical revascularization * Pregnancy or breastfeeding * Incapacity to provide informed consent

Design outcomes

Primary

Measure	Time frame	Description
Left ventricular ejection fraction recuperation 1 month post myocardial infarction	1 month post myocardial infarction	Left ventricular ejection fraction recuperation 1 month post myocardial infarction as compared with the left ejection fraction 3 months post myocardial infarction

Secondary

Measure	Time frame	Description
Anterior and apical akinesis recuperation 1 month post myocardial infarction	1 month post myocardial infarction	Anterior and apical akinesis recuperation 1 month post myocardial infarction as compared with 3 months post myocardial infarction

Countries

Canada

Outcome results