Hypercholesterolemia
Conditions
Keywords
simvastatin, alveolar bone, tooth extraction, remodeling, alveolar bone remodeling
Brief summary
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2. There have been many studies demonstrating the bone-promoting effect of local application various animal models including after application into socket of teeth in a rat. the purpose of the study is to investigate the effect of slow release topical simvastatin in socket of mandibular teeth on bone remodeling in the socket
Detailed description
after extraction of mandibular single root teeth 10 mg of slow release simvastatin would be inserted to the socket. observation will be at 1 week, 4 weeks and 3 months.after 3 months the patients will have dental CT as done routinely in our clinic before placing dental implants and the bone density and height will be measured on this data. during the procedure of inserting a dental implant a trephine will be taken for histology.
Interventions
DRUGSimvastatin
10 mg simvastatin, slow release in socket of extracted tooth (single application only)
Sponsors
Hadassah Medical Organization
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* need extraction of single root tooth * intend to have prosthetic implant in place of extraction
Exclusion criteria
* treated with simvastatin P.O for hypercholesterolemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| bone height and density in former socket | 3 months | measured on CT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bone mineralization | 3 months | histology from bone in former socket |
Countries
Israel
Contacts
Primary Contactcasap nardi, MD, DMD
Backup Contactrushinek heli, DMD
Outcome results
None listed