Dose Titration of Propofol for Tracheal Intubation in Children With Sevoflurane Inhalation Induction

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01084031

Enrollment

Registered

2010-03-10

Start date

2009-11-30

Completion date

2011-03-31

Last updated

2014-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric Urinary Disorders

Brief summary

Dose titration of propofol for tracheal intubation in children with sevoflurane inhalation induction.

Interventions

DRUGpropofol

intravenous propofol with sevoflurane inhalation induction

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

6 Months to 5 Years

Healthy volunteers

Inclusion criteria

* Pediatric patients scheduled for elective day case surgery were enrolled.

Exclusion criteria

* History of obstructive sleep apnea * Evidence of cardiorespiratory disease * Those who were obese or allergic to any of the anesthetic agents in this study * Those with an anticipated difficult airway, full stomach * History of malignant hyperthermia or other myopathy were excluded.

Design outcomes

Primary

Measure	Time frame	Description
Assessment of intubation conditions	30 minutes after the surgery	Assessment of intubation conditions (vocal cord, intubation condition, cough, movement) , peri-induction HR and BP change, post-operative agitation socre at recovery room. ED50 and ED 95 of each group by uring Dixon's up and down methods. peri -induction period -comparison of above factors among each groups (GroupA: ETSevo 3vol%, Group B: ETSevo 3.5vol%, Group: ET Sevo 4vol%)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026