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Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01083953
Enrollment
54
Registered
2010-03-10
Start date
2009-11-30
Completion date
2010-07-31
Last updated
2015-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway Complications

Keywords

end tidal concentration

Brief summary

The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response. Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.

Detailed description

The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction. With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research. Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.

Interventions

DRUGSevoflurane

Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

DRUGDesflurane

Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

Sponsors

Malaysian Society of Anaesthesiologists
CollaboratorOTHER
University of Malaya
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 49 Years
Healthy volunteers
Yes

Inclusion criteria

1. ASA 1-2 patients 2. Age 18 - 49 years old 3. Elective surgery of short duration ( \< 2 hours ) which require local anaesthetic infiltration

Exclusion criteria

1. Upper respiratory tract symptoms in the previous 10 days 2. Risk of gastric oesophageal reflux or regurgitation 3. Known or predicted difficult airway 4. Poor dentition with high risk of damage 5. BMI \> 30 kg/m2 6. Refusing to participate

Design outcomes

Primary

MeasureTime frame
Optimal end tidal concentration of sevoflurane/ desflurane6 months

Secondary

MeasureTime frame
presence of airway response10 mins after surgery

Countries

Malaysia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026