Minimal Hepatic Encephalopathy
Conditions
Keywords
Encephalopathy, Cirrhotics
Brief summary
This trial will study a possible effect of standard Israeli breakfast (30% of caloric value and 21 gram protein) on cognitive and executive functions (working memory, visual memory, concentration and coordination), on patients with mild-moderate liver cirrhosis.
Interventions
OTHERNutritional Intervention
Cognitive and executive functions before and after standard israeli breakfast (30% of caloric value and 21 gram protein)
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All consented adults (age \> 18), with the diagnosis of CHILD A cirrhosis with MELD score of \< 10. * Diagnosis of liver cirrhosis as documented by liver biopsy (stage IV) and / or fibroscan (score \> 12 kpa) and / or fibrotest (score \> 0.74) and /or imaging.
Exclusion criteria
* History of \> grade II hepatic encephalopathy (HE). * Diagnosis of dementia, Parkinson disease, Schizophrenia (Patients with major depression will be noted but not excluded). * Use of sedatives, tranquilizers or anti- psychotic medication during and/or 2 weeks prior to enrolling Use of antibiotics for any length of period during and/or 2 weeks prior to enrolling. * Current use of lactulose or neomycin. * Use of alcohol or elicit drugs during and/ or 6 months prior to enrolling.
Countries
Israel
Contacts
Primary ContactNachum Vaisman, Prof'
Outcome results
None listed