Oral Lichen Planus
Conditions
Keywords
Oral lichen planus, Minocycline, Dexamethasone
Brief summary
The aim of the present study is to assess the clinical efficacy of topical minocyclin in managing of symptoms associated with oral lichen planus (OLP). The rationale of the study is based on our previous studies demonstrating the beneficial effect of minocyclin mouthwash on recurrent aphthous stomatitis. The planned study will be a randomized controlled, cross-over trail. Patients with symptomatic OLP will randomly receive minocycline or dexamethasone rinses. The patients will rinse and expectorate 5 ml of the 1st mouthwash 4 times daily for 14 days. Subjects will complete a daily follow-up form that includes data regarding the daily intensity of pain (using VAS) caused by OLP and regarding possible side effects. After a washout period (at least 14 days) the patients will repeat the protocol with the second mouthwash.
Interventions
DRUGMinocycline
Minocycline 0.2% mouthwash
DRUGDexamethasone
Dexamethasone 0.01% mouthwash
Sponsors
Sheba Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* OLP patients (Biopsy proven)
Exclusion criteria
* Known allergy to Dexamethasone or Minocycline * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| symptoms relief | 2 years |
Contacts
Primary ContactNoam Yarom, DMD
Outcome results
None listed