Essential Hypertension, Hypertension, Resistant Hypertension
Conditions
Brief summary
The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.
Interventions
DRUGchlorthalidone
chlorthalidone 25mg/d vs. chlorthalidone 50mg/d
BEHAVIORALmotivational intervention for non-compliant individuals
motivational interview(s) vs. repeated calls vs. no particular intervention
DRUGstandardized anti-hypertensive treatment
olmesartan, amlodipine, chlorthalidone, +- spironolactone
Sponsors
University Hospital, Geneva
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* informed consent * resistant hypertension at the moment of inclusion * 18 years or more, both sexes are included * women at reproductive age: consenting to use oral contraception
Exclusion criteria
* patients mentally impaired or unable to give informed consent * patients speaking only a foreign language other than French, German, or English * patients living far away, making the study visits not practical
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure control | at 12 weeks after initiation of standard treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cardiovascular morbidity and mortality | 5 years | additional secondary: BP control at yearly follow-up |
Countries
Switzerland
Outcome results
None listed