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Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers

Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01082484
Acronym
INFLUX-IT-VS
Enrollment
20
Registered
2010-03-08
Start date
2010-01-31
Completion date
2011-01-31
Last updated
2011-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Healthy volunteers, iontophoresis

Brief summary

The purpose of this study is to test whether prostacyclin analogues' cathodal iontophoresis induce a cutaneous vasodilation in healthy volunteers's forearm, without local side effects.

Interventions

DRUGtreprostinil

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

DRUGiloprost

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

DRUGNaCl 0.9%

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

Sponsors

University Hospital, Grenoble
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* healthy volunteers * age above 18

Exclusion criteria

* any chronic disease * any drug intake

Design outcomes

Primary

MeasureTime frame
Amplitude of forearm cutaneous vasodilatation assessed using laser Doppler imaging24 hours

Secondary

MeasureTime frame
Local tolerance assessed clinicallyDay 0 and after 7 days

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026