Comparison of Lidocaine and Remifentanil for the Effect on Responses to the Endotracheal Tube During Emergence From General Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01082458

Enrollment

Registered

2010-03-08

Start date

2010-02-28

Completion date

2010-07-31

Last updated

2010-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroidectomy

Keywords

Patients scheduled to undergo thyroidectomy

Brief summary

Target concentration infusion(TCI) of remifentanil (2.0ng/ml) suppresses the cough induced by endotracheal tube more effectively than intravenous administration of lidocaine (1.5mg/kg).

Interventions

DRUGremifentanil / lidocaine

Remifentanil TCI group : target controlled infusion of 2.0ng/ml of remifentanil on end of surgery. Lidocaine IV group : Intravenous administration of 1.5mg/kg of lidocaine on end of surgery.

Study design

Primary purpose

PREVENTION

Eligibility

Sex/Gender

FEMALE

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Females older than 20 years old

Exclusion criteria

* Patients with acute or chronic respiratory disease, hypertension, gastro-esophageal reflux disease, having preoperative sedatives or mucolytics, and current smoker.

Design outcomes

Primary

Measure	Time frame	Description
Comparison of lidocaine and remifentanil for the effect on responses to the endotracheal tube during emergence from general anesthesia	—	The incidence and the grade of cough during emergence from general anensthesia between remifentanil TCI group and lidocaine IV administration group.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026