Sleep Deprivation
Conditions
Keywords
Sleep, Critical Illness, Sleep promotion during recovery form illness
Brief summary
Sleep deprivation in healthy volunteers is associated with immune dysfunction. This adverse effect of sleep deprivation likely occurs in patients suffering from acute injury and critical illness requiring intensive care unit (ICU) admission. Studies have demonstrated that sleep in ICU patients is highly abnormal. The global hypothesis for this proposal is that a strategy to promote sleep in ICU patients will increase time in rapid eye movement (REM) and slow wave sleep (SWS). This three phase proposal examines the feasibility of a sleep promotion strategy for injured and critically ill patients in the ICU. Phase I (Development and Training): Develop an intervention manual for sleep promotion, Sleep Enhancement Program (SEP), and train ICU staff. Phase II (Validation and Safety): Implement SEP and test for protocol fidelity and safety. Phase III (Efficacy): Conduct a pilot trail to determine efficacy of SEP to improve SWS in ICU patients.
Interventions
OTHERSleep Enhancement Program (SEP)
Sleep promotion in the ICU Multifaceted tool to promote sleep in ICU patients
Sponsors
Arizona Biomedical Research Commission (ABRC)
University of Arizona
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Received care in ICU for at least 3 days * Received care in ICU no longer than 14 days * Score of 3 to 5 on the Riker Sedation-Agitation Scale (SAS) * Age \< 55 years * Able to tolerate PO or have gastric access present (Nasogastric/Orogastric/PEG)
Exclusion criteria
* Pregnancy * Incarceration * Admission diagnosis of Closed Head Injury or Traumatic Brain Injury * Evidence of delirium on Confusion Assessment Method (CAM-ICU) Score * Hemodynamic Instability * Sepsis * Multiple Organ Dysfunction * Acute Renal Failure * Known history of sleep disorder * Known Psychiatric disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time in Rapid Eye Movement (REM) Sleep | Within 24 hours of enrollment | Polysomnography during sleep promotion protocol |
| Time in slow wave sleep | Within 24 hours of enrollment | Polysomnography during sleep promotion protocol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Systemic inflammatory mediators (cytokines) | Baseline and 12, 24, and 48 hours | Blood draw for circulating mediaotors of inflammation |
| Safety profile | With 24 hours of enrollment | Monitor for adverse events during polysomnography |
Countries
United States
Outcome results
None listed